ABO and FUT2 Genetic Transcription Effects on ABH Histo-blood Group Antigens in Lung Cancer Patients

Lung cancer is one of the major health issues in China and the burden is getting serious. Aging is the main cause for the increasing incidence and mortality of lung cancer (Chen et al., 2010; Chen et al., 2011). There are more than one-hundred recognized blood group systems (BGA), containing more than 500 antigens. The ABO (including A, B, H antigens) and Lewis (Lea, Leb, Lex, Ley) systems are the most common means used to classify blood. Blood group isoantigens of the ABH system are represented by a variety of glycoproteins and glycolipids, the antigenic specificity of which is determined by variation in their constituent carbohydrate chains. These antigens are not confined to red blood cells but are present on other cell types, such as endothelial cells, many normal/cancerous epithelial cells and in secretions(histo-blood group antigen) (Kay, 1957). Aberrant expression of the ABH and Lewis antigens